TY  -  JOUR
AU  -  Mansueto, Morena Luce
AU  -  Goldoni, Anna
AU  -  Zinani, Isotta
AU  -  Cantiello, Sara
AU  -  Fiandri, Giulia
AU  -  Bonvicini, Federico
AU  -  Zagni, Giulia
AU  -  Cappella, Michela
AU  -  Iughetti, Lorenzo
AU  -  De Fanti, Alessandro
T1  -  Sindrome DRESS: quando la pillola non va giù
PY  -  2023
Y1  -  2023-04-01
DO  -  10.1725/4058.40410
JO  -  Area Pediatrica
JA  -  AreaPed
VL  -  24
IS  -  2
SP  -  89
EP  -  92
PB  -  Il Pensiero Scientifico Editore
SN  -  2385-0736
Y2  -  2026/04/17
UR  -  http://dx.doi.org/10.1725/4058.40410
N2  -  <p><strong>Riassunto</strong></p>
<p>La sindrome &ldquo;Drug reaction with eosinophilia and systemic symptoms&rdquo; (DRESS) &egrave; una reazione di ipersensibilit&agrave; indotta da farmaci che si manifesta in pazienti con predisposizione genetica. Si presenta con anomalie ematologiche, principalmente eosinofilia, e coinvolgimento sistemico, in particolare cutaneo. Pu&ograve; concomitare anche la riattivazione di virus erpetici, come Human Herpes Virus 6-7 (HHV6-7) e virus di Epstein-Barr (EBV). Farmaci spesso responsabili di questo quadro sono Fenitoina, Fenobarbitale e Carbamazepina. Bench&egrave; l&rsquo;Oxcarbazepina sia considerata pi&ugrave; sicura, in letteratura &egrave; stata descritta questa reazione avversa. I criteri diagnostici della sindrome DRESS sono stati proposti dal <em>European Registry of Severe Cutaneous Adverse Reactions to Drugs and Collection of Biological Samples</em> (RegiSCAR). Nel nostro articolo descriviamo un raro caso di sindrome DRESS indotta dall&rsquo; Oxcarbazepina in una bambina di 12 anni con una forma di epilessia focale su base genetica.</p>
<p><strong>Parole chiave</strong>: DRESS, antiepilettici, eosinofilia, eritema, febbre persistente.</p>
<p><strong>&nbsp;</strong></p>
<p><strong>Summary</strong></p>
<p>Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a multiorgan hypersensitivity reaction caused by drugs that occurs in patients with a genetic predisposition.&nbsp;It consists of hematological abnormalities, especially eosinophilia, and multi-organ involvement, in particular skin can be affected. Viral reactivation of Human Herpes Virus 6-7 (HHV6-7) and Epstein-Barr virus (EBV) is another key-feature. DRESS can be induced by anticonvulsants such as Phenytoin, Phenobarbital, and Carbamazepine. Oxcarbazepine is considered a safer drug and DRESS syndrome after its administration is not common, but it has been described in literature. The most used diagnostic criteria for DRESS syndrome are proposed by the European Registry of Severe Cutaneous Adverse Reactions to Drugs and Collection of Biological Samples (RegiSCAR) group. In our article we describe an unusual case of DRESS syndrome induced by Oxcarbazepine in a 12-year-old girl with a form of focal genetic epilepsy.</p>
<p><strong>Key words: </strong>DRESS, anticonvulsants, eosinophilia, rash, persistent fever.</p>
ER  -